Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) is the latest identified subtype of 17β HSDs. In vivo this enzyme oxidizes the hydroxyl group at position 17 of estradiol (E2) and 5 androstenediol (5-diol) in the presence of NAD+ as cofactor. Two isoforms of this cytosolic protein exist that dif...

Ful tanımlama

Detaylı Bibliyografya

Yazar:	Bertoletti, Nicole
Diğer Yazarlar:	Klebe, Gerhard (Prof. Dr.) (Tez danışmanı)
Materyal Türü:	Dissertation
Dil:	İngilizce
Baskı/Yayın Bilgisi:	Philipps-Universität Marburg 2017
Konular:	Strukturbestimmung 17b-HSD14 crystallography, Fragment Screening Drug design Kristallstrukturen Inhibitoren im Komplex mit dem Protein Biowissenschaften, Biologie Inhibitor-Protein complex Life sciences
Online Erişim:	PDF Tam Metin
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!