Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) is the latest identified subtype of 17β HSDs. In vivo this enzyme oxidizes the hydroxyl group at position 17 of estradiol (E2) and 5 androstenediol (5-diol) in the presence of NAD+ as cofactor. Two isoforms of this cytosolic protein exist that dif...

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Autor principal:	Bertoletti, Nicole
Outros Autores:	Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Formato:	Dissertation
Idioma:	inglês
Publicado em:	Philipps-Universität Marburg 2017
Assuntos:	Strukturbestimmung 17b-HSD14 crystallography, Fragment Screening Drug design Kristallstrukturen Inhibitoren im Komplex mit dem Protein Biowissenschaften, Biologie Inhibitor-Protein complex Life sciences
Acesso em linha:	Texto integral em PDF
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