Investigations on lin-Benzopurines With Respect to Dissociation Behavior, Pocket Cross-Talk, Targeting Resistance Mutants, Residual Mobility, and Scaffold Optimization

The present thesis deals with the characterization and improvement of selective antibiotics targeting the enzyme tRNA–guanine transglycosylase. Recently, the lin-benzopurine scaffold was introduced as promising starting point for the structure-based design of TGT inhibitors. Two classes, namely the...

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Detaylı Bibliyografya

Yazar:	Neeb, Manuel
Diğer Yazarlar:	Klebe, Gerhard (Prof. Dr.) (Tez danışmanı)
Materyal Türü:	Dissertation
Dil:	İngilizce
Baskı/Yayın Bilgisi:	Philipps-Universität Marburg 2014
Konular:	isothermal titration calorimetry Wirkstoffdesign enzyme inhibition drug design X-ray crystallography Transferase Enzyminhibition Isothermale Titrationskalorimetrie Medizin Proteinkristallographie transferase Medical sciences Medicine
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