Investigations on lin-Benzopurines With Respect to Dissociation Behavior, Pocket Cross-Talk, Targeting Resistance Mutants, Residual Mobility, and Scaffold Optimization
The present thesis deals with the characterization and improvement of selective antibiotics targeting the enzyme tRNA–guanine transglycosylase. Recently, the lin-benzopurine scaffold was introduced as promising starting point for the structure-based design of TGT inhibitors. Two classes, namely the...
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Format: | Dissertation |
Sprache: | Englisch |
Veröffentlicht: |
Philipps-Universität Marburg
2014
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Online Zugang: | PDF-Volltext |
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PDF-VolltextSignatur: |
urn:nbn:de:hebis:04-z2014-04196 |
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Publikationsdatum: |
2014-11-18 |
Datum der Annahme: |
2014-11-05 |
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https://rightsstatements.org/vocab/InC-NC/1.0/ |
Zugangs-URL: |
https://archiv.ub.uni-marburg.de/diss/z2014/0419 https://doi.org/10.17192/z2014.0419 |