Investigations on lin-Benzopurines With Respect to Dissociation Behavior, Pocket Cross-Talk, Targeting Resistance Mutants, Residual Mobility, and Scaffold Optimization

The present thesis deals with the characterization and improvement of selective antibiotics targeting the enzyme tRNA–guanine transglycosylase. Recently, the lin-benzopurine scaffold was introduced as promising starting point for the structure-based design of TGT inhibitors. Two classes, namely the...

Description complète

Détails bibliographiques

Auteur principal:	Neeb, Manuel
Autres auteurs:	Klebe, Gerhard (Prof. Dr.) (Directeur de thèse)
Format:	Dissertation
Langue:	anglais
Publié:	Philipps-Universität Marburg 2014
Sujets:	isothermal titration calorimetry Wirkstoffdesign enzyme inhibition drug design X-ray crystallography Transferase Enzyminhibition Isothermale Titrationskalorimetrie Medizin Proteinkristallographie transferase Medical sciences Medicine
Accès en ligne:	Texte intégral en PDF
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!