Investigations on lin-Benzopurines With Respect to Dissociation Behavior, Pocket Cross-Talk, Targeting Resistance Mutants, Residual Mobility, and Scaffold Optimization

The present thesis deals with the characterization and improvement of selective antibiotics targeting the enzyme tRNA–guanine transglycosylase. Recently, the lin-benzopurine scaffold was introduced as promising starting point for the structure-based design of TGT inhibitors. Two classes, namely the...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолч:	Neeb, Manuel
Бусад зохиолчид:	Klebe, Gerhard (Prof. Dr.) (Дипломын ажлын зөвлөх)
Формат:	Dissertation
Хэл сонгох:	англи
Хэвлэсэн:	Philipps-Universität Marburg 2014
Нөхцлүүд:	isothermal titration calorimetry Wirkstoffdesign enzyme inhibition drug design X-ray crystallography Transferase Enzyminhibition Isothermale Titrationskalorimetrie Medizin Proteinkristallographie transferase Medical sciences Medicine
Онлайн хандалт:	PDF-н бүрэн текст
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!