Development of new inhibitors for the type II transmembrane serine protease matriptase

Several new inhibitors were prepared and tested as potential matriptase inhibitors. The most potent compounds were found among the tertiary amides of arylsulfonylated-3-amidinophenylalanines. The incorporation of suitable bis-substituted biphenylsulfonyl groups in combination with appropriate C-term...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखक: Hammami Maya
अन्य लेखक: Steinmetzer, Torsten (Prof. Dr.) (शोध सलाहकार)
स्वरूप: Dissertation
भाषा:अंग्रेज़ी
प्रकाशित: Philipps-Universität Marburg 2012
विषय:
ऑनलाइन पहुंच:पीडीएफ पूर्ण पाठ
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विवरण
सारांश:Several new inhibitors were prepared and tested as potential matriptase inhibitors. The most potent compounds were found among the tertiary amides of arylsulfonylated-3-amidinophenylalanines. The incorporation of suitable bis-substituted biphenylsulfonyl groups in combination with appropriate C-terminal urea structures provided the final strong potent monobasic matriptase inhibitors with acceptable selectivity against related trypsin-like serine proteases. Such compounds are suitable candidates for their further evaluation in cell culture experiments to elucidate the potential role of matriptase in pathophysiological processes
डिजिटल ऑब्जेक्ट पहचानकर्ता:10.17192/z2012.0955