Development of new inhibitors for the type II transmembrane serine protease matriptase

Development of new inhibitors for the type II transmembrane serine protease matriptase

Several new inhibitors were prepared and tested as potential matriptase inhibitors. The most potent compounds were found among the tertiary amides of arylsulfonylated-3-amidinophenylalanines. The incorporation of suitable bis-substituted biphenylsulfonyl groups in combination with appropriate C-term...

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Detaylı Bibliyografya
Yazar: Hammami Maya
Diğer Yazarlar: Steinmetzer, Torsten (Prof. Dr.) (Tez danışmanı)
Materyal Türü: Dissertation
Dil:İngilizce
Baskı/Yayın Bilgisi: Philipps-Universität Marburg 2012
Konular:
Matriptase
H9N2 influenza virus
Cancer, Influenza
Inhibitors
Naturwissenschaften
Serinprotease
Cancer
Natural sciences & mathematics
Online Erişim:PDF Tam Metin
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Özet:Several new inhibitors were prepared and tested as potential matriptase inhibitors. The most potent compounds were found among the tertiary amides of arylsulfonylated-3-amidinophenylalanines. The incorporation of suitable bis-substituted biphenylsulfonyl groups in combination with appropriate C-terminal urea structures provided the final strong potent monobasic matriptase inhibitors with acceptable selectivity against related trypsin-like serine proteases. Such compounds are suitable candidates for their further evaluation in cell culture experiments to elucidate the potential role of matriptase in pathophysiological processes
DOI:10.17192/z2012.0955

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