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Investigations on the biosynthesis of secondary metabolites and biosynthetic enzymes from Aspergillus species

In this thesis, BGCs for secondary metabolites from A. ustus have been investigated via multiple approaches. The identified PKS-containing utt BGC and two similar NRPS-containing opa and opa2 BGCs from the same fungus A. ustus demonstrated clearly the large fungal potential for natural product produ...

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Wedi'i Gadw mewn:
Prif Awdur: Zheng, Liujuan
Awduron Eraill: Li, Shu-Ming (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat: Dissertation
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2021
Pynciau:
Biowissenschaften, Biologie
nichtribosomalen Peptidsynthasen
Sekundärmetabolite
nonribosomal peptides
biosynthesis
Biosynthese
Pilzen
Polyketidsyntasen
polyketides
secondary metabolites
Fungi
Life sciences
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Disgrifiad
Crynodeb:In this thesis, BGCs for secondary metabolites from A. ustus have been investigated via multiple approaches. The identified PKS-containing utt BGC and two similar NRPS-containing opa and opa2 BGCs from the same fungus A. ustus demonstrated clearly the large fungal potential for natural product production and new enzyme discovery. In addition, site-directed mutagenesis for a fungal PT led to the functional switching with enhanced conversion yields, indicating that site-directed mutagenesis is an effective tool to increase the structural diversity of natural products.
Disgrifiad Corfforoll:276 Seiten
DOI:10.17192/z2021.0219

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