Investigations on the biosynthesis of secondary metabolites and biosynthetic enzymes from Aspergillus species

In this thesis, BGCs for secondary metabolites from A. ustus have been investigated via multiple approaches. The identified PKS-containing utt BGC and two similar NRPS-containing opa and opa2 BGCs from the same fungus A. ustus demonstrated clearly the large fungal potential for natural product produ...

Whakaahuatanga katoa

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Kaituhi matua: Zheng, Liujuan
Ētahi atu kaituhi: Li, Shu-Ming (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Hōputu: Dissertation
Reo:Ingarihi
I whakaputaina: Philipps-Universität Marburg 2021
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Whakaahuatanga
Whakarāpopototanga:In this thesis, BGCs for secondary metabolites from A. ustus have been investigated via multiple approaches. The identified PKS-containing utt BGC and two similar NRPS-containing opa and opa2 BGCs from the same fungus A. ustus demonstrated clearly the large fungal potential for natural product production and new enzyme discovery. In addition, site-directed mutagenesis for a fungal PT led to the functional switching with enhanced conversion yields, indicating that site-directed mutagenesis is an effective tool to increase the structural diversity of natural products.
Whakaahuatanga ōkiko:276 Seiten
DOI:10.17192/z2021.0219