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Investigations on the biosynthesis of secondary metabolites and biosynthetic enzymes from Aspergillus species
In this thesis, BGCs for secondary metabolites from A. ustus have been investigated via multiple approaches. The identified PKS-containing utt BGC and two similar NRPS-containing opa and opa2 BGCs from the same fungus A. ustus demonstrated clearly the large fungal potential for natural product produ...
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| Materialtyp: | Dissertation |
| Språk: | engelska |
| Publicerad: |
Philipps-Universität Marburg
2021
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| Länkar: | PDF-fulltext |
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| Sammanfattning: | In this thesis, BGCs for secondary metabolites from A. ustus have been investigated via multiple approaches. The identified PKS-containing utt BGC and two similar NRPS-containing opa and opa2 BGCs from the same fungus A. ustus demonstrated clearly the large fungal potential for natural product production and new enzyme discovery. In addition, site-directed mutagenesis for a fungal PT led to the functional switching with enhanced conversion yields, indicating that site-directed mutagenesis is an effective tool to increase the structural diversity of natural products. |
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| Fysisk beskrivning: | 276 Seiten |
| DOI: | 10.17192/z2021.0219 |