APOE isoform-specific effects in isogenic human iPSC-derived neural cells

Alzheimer’s Disease (AD) remains the leading cause of dementia in the elderly, one for which there is still no cure. Efforts in AD drug development have largely focused on treating neuronal pathologies that appear relatively late in the disease. Most of this research is carried out in neuron-focused...

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Bibliographische Detailangaben

1. Verfasser:	Zulfiqar, Shadaan
Beteiligte:	Nieweg, Katja (Dr., Junior Prof.) (BetreuerIn (Doktorarbeit))
Format:	Dissertation
Sprache:	Englisch
Veröffentlicht:	Philipps-Universität Marburg 2019
Schlagworte:	APOE Astrocytes iPSC Alzheimer's DIsease CRISPR-Cas9 Pharmakologie, Therapeutik Pharmacology & therapeutics, prescription drugs
Online-Zugang:	PDF-Volltext
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