APOE isoform-specific effects in isogenic human iPSC-derived neural cells

APOE isoform-specific effects in isogenic human iPSC-derived neural cells

Alzheimer’s Disease (AD) remains the leading cause of dementia in the elderly, one for which there is still no cure. Efforts in AD drug development have largely focused on treating neuronal pathologies that appear relatively late in the disease. Most of this research is carried out in neuron-focused...

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Bibliographic Details
Main Author: Zulfiqar, Shadaan
Contributors: Nieweg, Katja (Dr., Junior Prof.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
Subjects:
APOE
Astrocytes
iPSC
Alzheimer's DIsease
CRISPR-Cas9
Pharmakologie, Therapeutik
Pharmacology & therapeutics, prescription drugs
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Call Number: urn:nbn:de:hebis:04-z2019-05174
Publication Date: 2020-06-25
Date of Acceptance: 2019-11-28
Downloads: 140 (2024), 139 (2023), 187 (2022), 83 (2021), 21 (2020)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2019/0517
https://doi.org/10.17192/z2019.0517

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