Synthetic lethal interactions between ATR and DNA polymerases as a novel concept for individualized cancer therapy

The chemical inhibition of the kinase ATR, a central regulator of the DNA damage response, eliminates subsets of cancer cells in different tumors. This effect is at least partly attributable to the synthetic lethal relationship between ATR and certain DNA repair genes. In a previous study of our lab...

Ful tanımlama

Detaylı Bibliyografya

Yazar:	Job, Albert
Diğer Yazarlar:	Gallmeier, Eike (Prof. Dr.) (Tez danışmanı)
Materyal Türü:	Dissertation
Dil:	İngilizce
Baskı/Yayın Bilgisi:	Philipps-Universität Marburg 2019
Konular:	ATR synthetic lethality DNA polymerases POLD1 cancer therapy PRIM1 Medizin DNA-Polymerasen synthetische Letalität Tumortherapie Medical sciences Medicine
Online Erişim:	PDF Tam Metin
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!