Synthetic lethal interactions between ATR and DNA polymerases as a novel concept for individualized cancer therapy

The chemical inhibition of the kinase ATR, a central regulator of the DNA damage response, eliminates subsets of cancer cells in different tumors. This effect is at least partly attributable to the synthetic lethal relationship between ATR and certain DNA repair genes. In a previous study of our lab...

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Detalles Bibliográficos

Autor principal:	Job, Albert
Otros Autores:	Gallmeier, Eike (Prof. Dr.) (Orientador)
Formato:	Dissertation
Lenguaje:	inglés
Publicado:	Philipps-Universität Marburg 2019
Materias:	ATR synthetic lethality DNA polymerases POLD1 cancer therapy PRIM1 Medizin DNA-Polymerasen synthetische Letalität Tumortherapie Medical sciences Medicine
Acceso en línea:	Texto Completo PDF
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