Synthetic lethal interactions between ATR and DNA polymerases as a novel concept for individualized cancer therapy

The chemical inhibition of the kinase ATR, a central regulator of the DNA damage response, eliminates subsets of cancer cells in different tumors. This effect is at least partly attributable to the synthetic lethal relationship between ATR and certain DNA repair genes. In a previous study of our lab...

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Kaituhi matua:	Job, Albert
Ētahi atu kaituhi:	Gallmeier, Eike (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Hōputu:	Dissertation
Reo:	Ingarihi
I whakaputaina:	Philipps-Universität Marburg 2019
Ngā marau:	ATR synthetic lethality DNA polymerases POLD1 cancer therapy PRIM1 Medizin DNA-Polymerasen synthetische Letalität Tumortherapie Medical sciences Medicine
Urunga tuihono:	Kuputuhi katoa PDF
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!