Regulation of Rho-activating proteins by heterotrimeric G proteins: Sensitivity of Gα RhoGEF interaction is determined by dissociation kinetics

Activation of RhoGTPases downstream of G protein coupled receptors is important for many physiological functions, such as blood pressure regulation. The subfamilies Rho, Rac and Cdc42 are the best understood RhoGTPases and the present study focused on signaling towards the Rho subfamily member RhoA....

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Príomhchruthaitheoir:	Bodmann, Eva-Lisa
Rannpháirtithe:	Bünemann, Moritz (Prof.) (Comhairleoir tráchtais)
Formáid:	Dissertation
Teanga:	Béarla
Foilsithe / Cruthaithe:	Philipps-Universität Marburg 2014
Ábhair:	Gα13 Gαq Biowissenschaften, Biologie Regulator of G protein signaling 2 p63RhoGEF Förster resonance energy transfer Fluoreszenz-Resonanz-Energie-Transfer leukemia-associated RhoGEF G-Protein gekoppelte Rezeptoren Leukämie assoziiertes RhoGEF Life sciences
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