Structural and Functional Studies of tRNA-Guanine Transglycosylase: A putative Drug Target for Shigellosis Therapy

In this study structure-based drug design approaches for Zymomonas mobilis tRNA - guanine transglycosylase (TGT) are presented. In Shigella sp., the causative agent of bacterial shigellosis, TGT is involved in pathogenicity. Concerning the amino acid sequence, TGTs from both genera are highly h...

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Manylion Llyfryddiaeth

Prif Awdur:	Stengl, Bernhard
Awduron Eraill:	Klebe, Gerhard (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat:	Dissertation
Iaith:	Saesneg
Cyhoeddwyd:	Philipps-Universität Marburg 2006
Pynciau:	Transglycosylase Aminoacyl-tRNS Enzyminhibitor tRNA Medizin Strukturbasiertes Design lin-Benzoguanin Shigella Basenaustausch Kristallstrukturanalyse Zymomonas mobilis Bakterienruhr TGT Structure-based drug design Base exchange Transglykosylase Medical sciences Medicine
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