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Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here,...

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Wedi'i Gadw mewn:
Prif Awduron: van Geffen, Chiel, Heiss, Constantin, Deißler, Astrid, Kolahian, Saeed
Fformat: Erthygl
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2022
Pynciau:
pharmacotherapy
inflammation
MDSC
Medizin
immunomodulation
immune suppression
Medical sciences Medicine
Mynediad Ar-lein:Testun PDF llawn
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Disgrifiad
Crynodeb:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.
Disgrifiad o'r Eitem:Gefördert durch den Open-Access-Publikationsfonds der UB Marburg.
Disgrifiad Corfforoll:26 Seiten
DOI:10.3389/fimmu.2022.933847

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