صورة الغلاف

Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here,...

وصف كامل

محفوظ في:
المؤلفون الرئيسيون: van Geffen, Chiel, Heiss, Constantin, Deißler, Astrid, Kolahian, Saeed
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Philipps-Universität Marburg 2022
الموضوعات:
pharmacotherapy
inflammation
MDSC
Medizin
immunomodulation
immune suppression
Medical sciences Medicine
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الوصف
الملخص:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.
وصف المادة:Gefördert durch den Open-Access-Publikationsfonds der UB Marburg.
وصف مادي:26 Seiten
DOI:10.3389/fimmu.2022.933847

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