Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Ligand Complexes
Most biomolecular interactions occur in aqueous environment. Therefore, one must consider the interactions between proteins and water molecules when developing a drug molecule against a target protein. The study of these interactions is challenging using experimental techniques alone, therefore comp...
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| 格式: | Dissertation |
| 语言: | 英语 |
| 出版: |
Philipps-Universität Marburg
2019
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| 主题: | |
| 在线阅读: | PDF-Volltext |
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PDF-Volltext| 索引号: |
urn:nbn:de:hebis:04-z2019-04947 |
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| Publikationsdatum: |
2019-09-11 |
| Datum der Annahme: |
2019-10-22 |
| Downloads: |
21 (2025), 175 (2024), 140 (2023), 87 (2022), 61 (2021), 13 (2020) |
| Lizenz: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 访问URL: |
https://archiv.ub.uni-marburg.de/diss/z2019/0494 https://doi.org/10.17192/z2019.0494 |