Regulation of Rho-activating proteins by heterotrimeric G proteins: Sensitivity of Gα RhoGEF interaction is determined by dissociation kinetics

Activation of RhoGTPases downstream of G protein coupled receptors is important for many physiological functions, such as blood pressure regulation. The subfamilies Rho, Rac and Cdc42 are the best understood RhoGTPases and the present study focused on signaling towards the Rho subfamily member RhoA....

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Autor principal:	Bodmann, Eva-Lisa
Altres autors:	Bünemann, Moritz (Prof.) (Assessor de tesis)
Format:	Dissertation
Idioma:	anglès
Publicat:	Philipps-Universität Marburg 2014
Matèries:	Gα13 Gαq Biowissenschaften, Biologie Regulator of G protein signaling 2 p63RhoGEF Förster resonance energy transfer Fluoreszenz-Resonanz-Energie-Transfer leukemia-associated RhoGEF G-Protein gekoppelte Rezeptoren Leukämie assoziiertes RhoGEF Life sciences
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