Schmerzwahrnehmung und Schmerzempfindung bei Progressiver Supranukleärer Blickparese (PSP)
Hintergrund: Ziel dieser experimentellen klinischen Untersuchung ist es, die Schmerzwahrnehmung und die subjektive Schmerzempfindung bei PSPPatienten zu untersuchen und sie mit denen von Parkinson-Patienten und gesunden Kontrollpersonen zu vergleichen. Es sollen erste Daten zur experimentellen S...
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| Format: | Dissertation |
| Sprache: | Deutsch |
| Veröffentlicht: |
Philipps-Universität Marburg
2013
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| Online-Zugang: | PDF-Volltext |
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Objective: The aim of this study was to assess spinal nociception and experimental pain sensitivity in progressive supranuclear palsy (PSP) compared to patients with Parkinson´s disease and healthy controls (HC). Methods: Spinal nociception as measured by the nociceptive flexion reflex (NFR) and experimental pain sensitivity as measured by heat and electrical pain thresholds were determined in the medication-defined “off-phase” in nondemented, non-depressed, probable PSP patients (N=8), PD patients (N=19) and 17 HC. Results: PSP patients exhibited lower electrical pain thresholds and a tendency for lower NFR thresholds as compared to HC. No significant differences between PSP and PD patients were found with respect to experimentallyinduced pain. However, significantly less PSP than PD patients reported clinical pain. Conclusions: Degeneration of the descending inhibitory control system within the brainstem in PSP might lead to increased nociception while frontal cortical deterioration may alter self-estimation of pain.