Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide (PACAP)-mediated activation of its G protein-coupled receptor PAC1 results in activation of the two G proteins Gs and Gq to alter second messenger generation and gene transcription in the nervous system, important for homeostatic responses to stress...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Holighaus, Yvonne
Awduron Eraill: Weihe, Eberhard (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat: Dissertation
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2011
Pynciau:
PACAP
Nervensystem
Neuropeptide
G protein-coupled receptors
gene expression
neuropharmacology
signal transduction
G-Protein gekoppelte Rezeptoren
Neuropharmakologie
nervous system
Signaltransduktion
Naturwissenschaften
stress
neuropeptides
Genexpression
Stress
Natural sciences & mathematics
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Manylion daliadau o
Rhif Galw: urn:nbn:de:hebis:04-z2011-05513
Dyddiad Cyhoeddi: 2011-08-29
Datum der Annahme: 2011-08-01
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL mynediad: https://archiv.ub.uni-marburg.de/diss/z2011/0551
https://doi.org/10.17192/z2011.0551

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