Towards Improved Aldose Reductase Inhibitors - Structural and Thermodynamic Investigation of Mutant and Wild Type Aldose Reductase Inhibitor Complexes

Rational drug design for flexible proteins like human aldose reductase comprises special challenges to find novel lead compounds or to improve known inhibitors. In this thesis, diverse aspects of the complexity of such a task were investigated to find promising new lead scaffolds and enhance the aff...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखक:	Koch, Cornelia
अन्य लेखक:	Klebe, Gerhard (Prof.) (शोध सलाहकार)
स्वरूप:	Dissertation
भाषा:	अंग्रेज़ी
प्रकाशित:	Philipps-Universität Marburg 2011
विषय:	Isothermal titration calorimetry Aldosereduktase drug design Wirkstoffdesign Chemie Wirkstoff-Rezeptor-Bindung aldose reductase diabetes Inhibitor Röntgenstrukturanalyse Isothermale Titrationskalorimetrie X-ray Diabetes mellitus Kalorimetrie Chemistry & allied sciences
ऑनलाइन पहुंच:	पीडीएफ पूर्ण पाठ
टैग:	टैग जोड़ें कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!