Towards Improved Aldose Reductase Inhibitors - Structural and Thermodynamic Investigation of Mutant and Wild Type Aldose Reductase Inhibitor Complexes

Rational drug design for flexible proteins like human aldose reductase comprises special challenges to find novel lead compounds or to improve known inhibitors. In this thesis, diverse aspects of the complexity of such a task were investigated to find promising new lead scaffolds and enhance the aff...

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Bibliographic Details
Main Author: Koch, Cornelia
Contributors: Klebe, Gerhard (Prof.) (Thesis advisor)
Format: Dissertation
Language:English
Published: Philipps-Universität Marburg 2011
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Call Number: urn:nbn:de:hebis:04-z2011-04163
Downloads: 15 (2021), 29 (2020), 19 (2019), 28 (2018), 45 (2017)
Publication Date: 2011-06-28
License: According to UrhG § 31 (2), the author has granted the University Library Marburg the right of use for electronic publication on the Internet and for archiving on its archive server. He has declared that with the granting of the right of use according to UrhG § 31 (3) no exclusive rights of third parties are violated. All other rights for the exploitation of the publication remain with the author. https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2011/0416
https://doi.org/10.17192/z2011.0416