Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design

Carbonyl reduction of aldehydes, ketones and quinones to their corresponding hydroxy de-rivatives plays an important role in the phase-I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens...

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Manylion Llyfryddiaeth

Prif Awdur:	Hoffmann-Geim, Frank
Awduron Eraill:	Buckel, Wolfgang (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat:	Dissertation
Iaith:	Saesneg
Cyhoeddwyd:	Philipps-Universität Marburg 2009
Pynciau:	Molekulardynamik Modellierung Biowissenschaften, Biologie Carbonyl-Reductase Hydroxysteroid-Dehydrogenasen Röntgenstruktur 3alpha HSD/CR Drug Design Hydroxysteroiddehydrogenase SDR Molecular dynamic Simulation Life sciences
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