Intermediärfilament- und GD2-Expression in astrozytären Hirntumoren

Intermediärfilament- und GD2-Expression in astrozytären Hirntumoren

In der Arbeit wird eine vergleichende, semiquantitative immunhistochemische Untersuchung der Expression von saurem Gliafaserprotein, Vimentin und Glykosphingolipid GD2 in 28 astrozytären Hirntumoren WHO Grad II-IV dargestellt. Statistisch findet sich eine hohe Korrelation sowohl der intrazellulären...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Lell, Barbara
Awduron Eraill: Mennel, H.D. (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat: Dissertation
Iaith:Almaeneg
Cyhoeddwyd: Philipps-Universität Marburg 2008
Pynciau:
Intermediärfilament
Medizin
Astrozytäre Hirntumoren
Astrocytic tumors
Glial fibrillary acidic protein GFAP, Glykosphingolipid GD2
Saures Gliafaserprotein GFAP
Glykosphingolipid GD2
Intermediary filaments
Medical sciences Medicine
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By means of immunhistochemical markers the expression of glial fibrillary acidic protein, vimentin and glykosphingolipid GD2 is investigated in 28 astrocytic tumors grading WHO II-IV. Statistically, there is found a high correlation in the cytoplasmatic expression of GFAP/GD2 as well as Vimentin/GD2 and GFAP/Vimentin.The semiquantitatively strongest expression was found in gemistocytic and protoplasmatic cells of the investigated glial tumors. As conclusion, astrocytic tumors express in a similar way intermediary filament GFAP and glykosphingolipid GD2. Whether or not a co-localisation of intermediary filaments and GD2 within the brain tumors takes place, remains open.

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