Structural and Functional Studies of tRNA-Guanine Transglycosylase: A putative Drug Target for Shigellosis Therapy

In this study structure-based drug design approaches for Zymomonas mobilis tRNA - guanine transglycosylase (TGT) are presented. In Shigella sp., the causative agent of bacterial shigellosis, TGT is involved in pathogenicity. Concerning the amino acid sequence, TGTs from both genera are highly h...

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Detalhes bibliográficos

Autor principal:	Stengl, Bernhard
Outros Autores:	Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Formato:	Dissertation
Idioma:	inglês
Publicado em:	Philipps-Universität Marburg 2006
Assuntos:	Transglycosylase Aminoacyl-tRNS Enzyminhibitor tRNA Medizin Strukturbasiertes Design lin-Benzoguanin Shigella Basenaustausch Kristallstrukturanalyse Zymomonas mobilis Bakterienruhr TGT Structure-based drug design Base exchange Transglykosylase Medical sciences Medicine
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