KLF4‑mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP

The immunoreceptor NKG2D, which is expressed on NK cells and T cell subsets is critically involved in tumor immune surveillance. This applies in particular to acute myeloid leukemia (AML), which evades immune detection by downregulation of NKG2D ligands (NKG2D-L), including MICA. The absence of NK...

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Autoren:	Alkhayer, Reem, Ponath, Vivane, Frech, Miriam, Adhikary, Till, Graumann, Johannes, Neubauer, Andreas, Pogge von Strandmann, Elke
Format:	Artikel
Sprache:	Englisch
Veröffentlicht:	Philipps-Universität Marburg 2023
Schlagworte:	Immunotherapy APTO253 Natural killer cells NKG2D/NKG2D-ligand axis Medizin Immune evasion Medical sciences Medicine
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