Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells

Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD). However, the non-canonical local, cellular functions of FHR-3 remained poorly understood. Here, we report that FHR-3 bound...

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Autoren:	Schäfer, Nicole, Rasras, Anas, Ormenisan, Delia M, Amslinger, Sabine, Enzmann, Volker, Jägle, Herbert, Pauly, Diana
Körperschaft:	Frontiers in Immunology (Herausgebendes Organ)
Format:	Artikel
Sprache:	Englisch
Veröffentlicht:	Philipps-Universität Marburg 2021
Schlagworte:	complosome AMD Medizin FHR-3 inflammation oxidative stress epitopes complement activation RETC-2, RPE cells FHR-3 alters RPE cell complosome Medical sciences Medicine
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