Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells

Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells

Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD). However, the non-canonical local, cellular functions of FHR-3 remained poorly understood. Here, we report that FHR-3 bound...

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Autoren: Schäfer, Nicole, Rasras, Anas, Ormenisan, Delia M, Amslinger, Sabine, Enzmann, Volker, Jägle, Herbert, Pauly, Diana
Körperschaft: Frontiers in Immunology (Herausgebendes Organ)
Format: Artikel
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2021
Schlagworte:
Medizin
oxidative stress epitopes
AMD
complosome
FHR-3
inflammation
RETC-2, RPE cells FHR-3 alters RPE cell complosome
complement activation
Medical sciences Medicine
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Signatur: urn:nbn:de:hebis:04-es2024-04079
Publikationsdatum: 2024-01-16
Quelle: Erstveröffentlichung: Schäfer N, Rasras A, Ormenisan DM, Amslinger S, Enzmann V, Jägle H and Pauly D (2021) Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells. Front. Immunol. 12:769242. https://doi.org/10.3389/fimmu.2021.769242
Downloads: 70 (2024)
Lizenz: https://creativecommons.org/licenses/by/4.0
Zugangs-URL: https://archiv.ub.uni-marburg.de/es/2024/0407
https://doi.org/10.3389/fimmu.2021.769242

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