Navigated Intraoperative 3D Ultrasound in Glioblastoma Surgery: Analysis of Imaging Features and Impact on Extent of Resection
Background: Neuronavigation is routinely used in glioblastoma surgery, but its accuracy decreases during the operative procedure due to brain shift, which can be addressed utilizing intraoperative imaging. Intraoperative ultrasound (iUS) is widely available, offers excellent live imaging, and can...
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| Autoren: | , , , , |
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| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
Philipps-Universität Marburg
2023
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| Online-Zugang: | PDF-Volltext |
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| Zusammenfassung: | Background: Neuronavigation is routinely used in glioblastoma surgery, but its
accuracy decreases during the operative procedure due to brain shift, which can
be addressed utilizing intraoperative imaging. Intraoperative ultrasound (iUS) is widely
available, offers excellent live imaging, and can be fully integrated into modern
navigational systems. Here, we analyze the imaging features of navigated i3D US and
its impact on the extent of resection (EOR) in glioblastoma surgery.
Methods: Datasets of 31 glioblastoma resection procedures were evaluated. Patient
registration was established using intraoperative computed tomography (iCT). Preoperative
MRI (pre-MRI) and pre-resectional ultrasound (pre-US) datasets were
compared regarding segmented tumor volume, spatial overlap (Dice coefficient), the
Euclidean distance of the geometric center of gravity (CoG), and the Hausdorff
distance. Post-resectional ultrasound (post-US) and post-operative MRI (post-MRI)
tumor volumes were analyzed and categorized into subtotal resection (STR) or gross
total resection (GTR) cases.
Results: The mean patient age was 59.3 � 11.9 years. There was no significant
difference in pre-resectional segmented tumor volumes (pre-MRI: 24.2 � 22.3 cm3; pre-
US: 24.0 � 21.8 cm3). The Dice coefficient was 0.71 � 0.21, the Euclidean distance of
the CoG was 3.9 � 3.0 mm, and the Hausdorff distance was 12.2 � 6.9 mm. A total of
18 cases were categorized as GTR, 10 cases were concordantly classified as STR on
MRI and ultrasound, and 3 cases had to be excluded from post-resectional analysis. In
four cases, i3D US triggered further resection.
Conclusion: Navigated i3D US is reliably adjunct in a multimodal navigational setup
for glioblastoma resection. Tumor segmentations revealed similar results in i3D US and
MRI, demonstrating the capability of i3D US to delineate tumor boundaries. Additionally,
i3D US has a positive influence on the EOR, allows live imaging, and depicts brain shift. |
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| Umfang: | 11 Seiten |
| DOI: | 10.3389/fnins.2022.883584 |