The multifaceted role of mutant p53 in remodeling the tumor transcriptome and secretome

The tumor suppressor gene TP53 is frequently inactivated by missense mutations in human cancers. These genetic alterations give rise to the expression of mutant variants of the encoded p53 protein (mutp53) that have lost their tumor-suppressive functions. Moreover, many mutp53 proteins acquire novel...

Ausführliche Beschreibung

Bibliographische Detailangaben

1. Verfasser:	Neumann, Michelle
Beteiligte:	Stiewe, Thorsten (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format:	Dissertation
Sprache:	Englisch
Veröffentlicht:	Philipps-Universität Marburg 2023
Schlagworte:	generation of in vitro and in vivo cancer models gene editing via CRISPR/Cas9 in cancer cell lines in vivo mutagenesis using CRISPR/Cas9 transcriptome and secretome analyses Medizin p53 mutant p53 cancer gain-of-function mutation CRISPR transcriptomics secretome lung cancer PDAC Krebs Medizin Medical sciences Medicine
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