Targeting ferroptosis for neuroprotection: Novel diphenylamine compounds targeting mitochondrial pathways of oxidative cell death

Targeting ferroptosis for neuroprotection: Novel diphenylamine compounds targeting mitochondrial pathways of oxidative cell death

Neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease as well as stroke are of growing concern in our aging societies. In the last decades, biochemical hallmarks of these pathologies, containing excessive lipid peroxide formation, iron overload and mitochondrial impairments were li...

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Autore principale: Hinder, Lukas
Altri autori: Culmsee, Carsten (Prof. Dr.) (Relatore della tesi)
Natura: Dissertation
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2021
Soggetti:
Mitochondrien
Oxidativer Zelltod
HT22 Zellen
BH3 interacting-domain death agonist
Naturwissenschaften
Diphenylamin Verbindungen
Oxidative cell death
DPA
Bid
ROS
Ferroptose
ferroptosis
neuroprotection
Natural sciences & mathematics
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