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Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis
TP53 is an essential tumor suppressor gene which is inactivated in every second tumor. Most frequently TP53 is disabled by missense mutations which result in the expression of a mutant p53 protein. Mutant p53 protein is unable to prevent uncontrolled proliferation and can additionally increase cance...
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| 主要作者: | |
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| 其他作者: | |
| 格式: | Dissertation |
| 語言: | 英语 |
| 出版: |
Philipps-Universität Marburg
2021
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| 主題: | |
| 在線閱讀: | PDF-Volltext |
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PDF-Volltext| 索引號: |
urn:nbn:de:hebis:04-z2021-02944 |
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| Publikationsdatum: |
2021-08-09 |
| Datum der Annahme: |
2021-06-21 |
| Downloads: |
83 (2024), 188 (2023), 233 (2022), 65 (2021) |
| Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
| Zugangs-URL: |
https://archiv.ub.uni-marburg.de/diss/z2021/0294 https://doi.org/10.17192/z2021.0294 |