Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

TP53 is an essential tumor suppressor gene which is inactivated in every second tumor. Most frequently TP53 is disabled by missense mutations which result in the expression of a mutant p53 protein. Mutant p53 protein is unable to prevent uncontrolled proliferation and can additionally increase cance...

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Bibliografske podrobnosti
Glavni avtor: Klimovich, Mariia
Drugi avtorji: Stiewe, Thorsten (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Jezik:angleščina
Izdano: Philipps-Universität Marburg 2021
Teme:
p53
Medizin
saturation mutagenesis
CRISPR/Cas9
Sättigungsmutagenese
Medical sciences Medicine
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Podrobnosti zaloge
Signatura: urn:nbn:de:hebis:04-z2021-02944
Publikationsdatum: 2021-08-09
Datum der Annahme: 2021-06-21
Downloads: 83 (2024), 188 (2023), 233 (2022), 65 (2021)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2021/0294
https://doi.org/10.17192/z2021.0294

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