Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

TP53 is an essential tumor suppressor gene which is inactivated in every second tumor. Most frequently TP53 is disabled by missense mutations which result in the expression of a mutant p53 protein. Mutant p53 protein is unable to prevent uncontrolled proliferation and can additionally increase cance...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autor: Klimovich, Mariia
Daljnji autori: Stiewe, Thorsten (Prof. Dr.) (Savjetnik disertacije)
Format: Dissertation
Jezik:engleski
Izdano: Philipps-Universität Marburg 2021
Teme:
p53
Medizin
saturation mutagenesis
CRISPR/Cas9
Sättigungsmutagenese
Medical sciences Medicine
Online pristup:PDF cijeli tekst
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Internet

PDF cijeli tekst

Detalji primjeraka od
Signatura: urn:nbn:de:hebis:04-z2021-02944
Datum izdanja: 2021-08-09
Datum der Annahme: 2021-06-21
Downloads: 78 (2024), 188 (2023), 233 (2022), 65 (2021)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL pristupa: https://archiv.ub.uni-marburg.de/diss/z2021/0294
https://doi.org/10.17192/z2021.0294

Slični predmeti