Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

TP53 is an essential tumor suppressor gene which is inactivated in every second tumor. Most frequently TP53 is disabled by missense mutations which result in the expression of a mutant p53 protein. Mutant p53 protein is unable to prevent uncontrolled proliferation and can additionally increase cance...

Cur síos iomlán

Sábháilte in:
Sonraí bibleagrafaíochta
Príomhchruthaitheoir: Klimovich, Mariia
Rannpháirtithe: Stiewe, Thorsten (Prof. Dr.) (Comhairleoir tráchtais)
Formáid: Dissertation
Teanga:Béarla
Foilsithe / Cruthaithe: Philipps-Universität Marburg 2021
Ábhair:
p53
Medizin
saturation mutagenesis
CRISPR/Cas9
Sättigungsmutagenese
Medical sciences Medicine
Rochtain ar líne:An téacs iomlán mar PDF
Clibeanna: Cuir clib leis
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!

Ar líne

An téacs iomlán mar PDF

Sonraí sealbhúcháin ó
Gairmuimhir: urn:nbn:de:hebis:04-z2021-02944
Dáta a fhoilsithe: 2021-08-09
Datum der Annahme: 2021-06-21
Downloads: 83 (2024), 188 (2023), 233 (2022), 65 (2021)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL Rochtana: https://archiv.ub.uni-marburg.de/diss/z2021/0294
https://doi.org/10.17192/z2021.0294

Míreanna comhchosúla