Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

TP53 is an essential tumor suppressor gene which is inactivated in every second tumor. Most frequently TP53 is disabled by missense mutations which result in the expression of a mutant p53 protein. Mutant p53 protein is unable to prevent uncontrolled proliferation and can additionally increase cance...

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Bibliographic Details
Main Author: Klimovich, Mariia
Contributors: Stiewe, Thorsten (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2021
Subjects:
p53
Medizin
saturation mutagenesis
CRISPR/Cas9
Sättigungsmutagenese
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2021-02944
Publication Date: 2021-08-09
Date of Acceptance: 2021-06-21
Downloads: 78 (2024), 188 (2023), 233 (2022), 65 (2021)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2021/0294
https://doi.org/10.17192/z2021.0294

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