Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

TP53 is an essential tumor suppressor gene which is inactivated in every second tumor. Most frequently TP53 is disabled by missense mutations which result in the expression of a mutant p53 protein. Mutant p53 protein is unable to prevent uncontrolled proliferation and can additionally increase cance...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Klimovich, Mariia
Awduron Eraill: Stiewe, Thorsten (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat: Dissertation
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2021
Pynciau:
p53
Medizin
saturation mutagenesis
CRISPR/Cas9
Sättigungsmutagenese
Medical sciences Medicine
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Manylion daliadau o
Rhif Galw: urn:nbn:de:hebis:04-z2021-02944
Dyddiad Cyhoeddi: 2021-08-09
Datum der Annahme: 2021-06-21
Downloads: 83 (2024), 188 (2023), 233 (2022), 65 (2021)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL mynediad: https://archiv.ub.uni-marburg.de/diss/z2021/0294
https://doi.org/10.17192/z2021.0294

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