Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

The first topic of this thesis (Chapter 2) presents a mutational study performed on 17β-hydroxysteroid dehydrogenase type 14 (17β-HSD14) S205 variant. Five different mutations were done with respect to five amino acids which are believed to have an essential role in the enzyme activity and assembly....

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Badran, Mohammed
Otros Autores: Klebe, Gerhard (Prof. Dr.) (Orientador)
Formato: Dissertation
Lenguaje:inglés
Publicado: Philipps-Universität Marburg 2021
Materias:
Biowissenschaften, Biologie
Inhibitoren im Komplex mit dem Protein Strukturbestimmung Kristallstrukturen 17b-HSD14 Fragment Screening crystallography, Inhibitor-Protein com
Life sciences
Acceso en línea:Texto Completo PDF
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

Texto Completo PDF

Detalle de Existencias desde
Número de Clasificación: urn:nbn:de:hebis:04-z2021-00954
Fecha de Publicación: 2021-12-02
Datum der Annahme: 2020-11-06
Downloads: 49 (2024), 129 (2023), 119 (2022), 12 (2021)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL de Acceso: https://archiv.ub.uni-marburg.de/diss/z2021/0095
https://doi.org/10.17192/z2021.0095

Ejemplares similares