From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme

From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme

Serendipity has played a historically significant role in science and especially in the discovery of new drugs. Chance discoveries have led to important drug developments that characterize the pharmaceutical industry and our current health care system. Over the last decades, the concept of rational...

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Bibliographic Details
Main Author: Nguyen, Dzung
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2020
Subjects:
Shigellose
Fragments
Assayentwicklung
El
Homodimer
Assay Development
Wirkstoffdesign
Proteine
Proteindynamik
Proteins
Biowissenschaften, Biologie
Shigellosis
Protein Dynamics
Fragmente
Antibiotics
Protein–Ligand-Wechselwirkung
Drug Design
Protein–Ligand Interaction
Inhibitoren
Inhibitors
Antibiotika
Life sciences
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Call Number: urn:nbn:de:hebis:04-z2021-00679
Publication Date: 2021-02-15
Date of Acceptance: 2021-01-15
Downloads: 113 (2024), 192 (2023), 153 (2022), 138 (2021)
License: https://creativecommons.org/licenses/by-nc-nd/4.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2021/0067
https://doi.org/10.17192/z2021.0067

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