Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), which mostly affects underprivileged populations in South and Central America. The current standard of care for this disease are the two empirically discovered drugs benznidazole and nifurtimox. They show low efficacy, diffi...

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主要作者: Petrick, Joy Kristin
其他作者: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
格式: Dissertation
语言:英语
出版: Philipps-Universität Marburg 2019
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索引号: urn:nbn:de:hebis:04-z2019-05018
Publikationsdatum: 2020-05-25
Datum der Annahme: 2019-09-12
Downloads: 74 (2024), 149 (2023), 183 (2022), 158 (2021), 49 (2020)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
访问URL: https://archiv.ub.uni-marburg.de/diss/z2019/0501
https://doi.org/10.17192/z2019.0501