Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), which mostly affects underprivileged populations in South and Central America. The current standard of care for this disease are the two empirically discovered drugs benznidazole and nifurtimox. They show low efficacy, diffi...
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格式: | Dissertation |
语言: | 英语 |
出版: |
Philipps-Universität Marburg
2019
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在线阅读: | PDF-Volltext |
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PDF-Volltext索引号: |
urn:nbn:de:hebis:04-z2019-05018 |
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Publikationsdatum: |
2020-05-25 |
Datum der Annahme: |
2019-09-12 |
Downloads: |
74 (2024), 149 (2023), 183 (2022), 158 (2021), 49 (2020) |
Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
访问URL: |
https://archiv.ub.uni-marburg.de/diss/z2019/0501 https://doi.org/10.17192/z2019.0501 |