Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

There are several biophysical methods developed to rapidly identify weakly binding fragments to a target protein. X-ray crystallography provides structural information that is crucial for fragment optimization, however there are several criteria that must be met for a successful fragment screening...

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主要作者:	Hassaan, Engi
其他作者:	Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
格式:	Dissertation
语言:	英语
出版:	Philipps-Universität Marburg 2019
主题:	drug discovery x-ray crystallography comparative analysis fragment screening NMR tRNA guanine transglycosylase endothiapepsin peroxin 14 SPR Pharmakologie, Therapeutik Pharmacology & therapeutics, prescription drugs
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