Nuclear factor of activated T-cells, NFATC1, governs FLT3-ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML

Nuclear factor of activated T-cells, NFATC1, governs FLT3-ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML

Internal tandem duplication ITD-mutated FMS-like Tyrosine Kinase-3 (FLT3) is associated with poor prognosis in patients with acute myeloid leukemia (AML). In mouse models, it has been shown that although FLT3ITD increases proliferation of the hematopoietic stem cells (HSC), it doesn't lead to...

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Bibliografiske detaljer
Hovedforfatter: Solovey, Maria
Andre forfattere: Burchert, Andreas (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprog:engelsk
Udgivet: Philipps-Universität Marburg 2019
Fag:
Medizin
FLT3-ITD
NFATC1
AML
Medical sciences Medicine
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