Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) is the latest identified subtype of 17β HSDs. In vivo this enzyme oxidizes the hydroxyl group at position 17 of estradiol (E2) and 5 androstenediol (5-diol) in the presence of NAD+ as cofactor. Two isoforms of this cytosolic protein exist that dif...

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Detalles Bibliográficos
Autor principal: Bertoletti, Nicole
Otros Autores: Klebe, Gerhard (Prof. Dr.) (Orientador)
Formato: Dissertation
Lenguaje:inglés
Publicado: Philipps-Universität Marburg 2017
Materias:
17b-HSD14
Kristallstrukturen
crystallography,
Fragment Screening
Drug design
Biowissenschaften, Biologie
Strukturbestimmung
Inhibitor-Protein complex
Inhibitoren im Komplex mit dem Protein
Life sciences
Acceso en línea:Texto Completo PDF
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