Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin
In the pre-clinical development stages of most drug design campaigns, the equilibrium binding affinity of a prospective lead candidate, in the form of an IC50, Kd or ΔG° value, is the most commonly employed benchmark parameter for its effectiveness as a putative drug. Hydrogen bonding, van der Waals...
Sábháilte in:
Príomhchruthaitheoir: | |
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Rannpháirtithe: | |
Formáid: | Dissertation |
Teanga: | Béarla |
Foilsithe / Cruthaithe: |
Philipps-Universität Marburg
2017
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Ábhair: | |
Rochtain ar líne: | An téacs iomlán mar PDF |
Clibeanna: |
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Ar líne
An téacs iomlán mar PDFGairmuimhir: |
urn:nbn:de:hebis:04-z2017-04658 |
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Dáta a fhoilsithe: |
2018-08-08 |
Datum der Annahme: |
2017-06-09 |
Downloads: |
102 (2024), 99 (2023), 58 (2022), 37 (2021), 24 (2020), 36 (2019), 11 (2018) |
Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
URL Rochtana: |
https://archiv.ub.uni-marburg.de/diss/z2017/0465 https://doi.org/10.17192/z2017.0465 |