Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin

In the pre-clinical development stages of most drug design campaigns, the equilibrium binding affinity of a prospective lead candidate, in the form of an IC50, Kd or ΔG° value, is the most commonly employed benchmark parameter for its effectiveness as a putative drug. Hydrogen bonding, van der Waals...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awdur:	Cramer, Jonathan
Awduron Eraill:	Klebe, Gerhard (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat:	Dissertation
Iaith:	Saesneg
Cyhoeddwyd:	Philipps-Universität Marburg 2017
Pynciau:	SPR Thermodynamik Thermolysin Synthese Phosphonamidat Kinetik Chemische Synthese Wirkstoff Phosphonamidate Kinetics ITC Proteine Thermodynamics Synthesis Bindungskinetik Chemie Chemistry & allied sciences
Mynediad Ar-lein:	Testun PDF llawn
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!