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From Active-Site Mapping to Lead Discovery using Fragment-based Approaches on the Aspartic protease Endothiapepsin
The work focuses on the evaluation and comparison of different fragment-based approaches, for which purpose the model system Endothiapepsin (EP) has been used. The enzyme belongs to the family of aspartic proteases. We used the 361-entry in-house fragment library compiled with physico-chemical pro...
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| Формат: | Dissertation |
| Язык: | английский |
| Опубликовано: |
Philipps-Universität Marburg
2016
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| Online-ссылка: | PDF-полный текст |
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